Questions and Answers

About neriaTM infusion sets and indications

What is a neria™ infusion set?

neria™ infusion sets are medical devices designed for subcutaneous drug delivery. The infusion set is located in the subcutaneous tissues and connects the pump or syringe to the body.

The components of an infusion set include: 

  1. Needle and/or cannula - the cannula is inserted under the skin using an introducer needle
  2. Adhesive dressing - built-in and skin friendly adhesive pad
  3. Tubing – a double layer tubing that prevents kinking and secures the flow of medication to the tissue
  4. Luer lock connector – a standard connector to the syringe or pump
What are the indications and intended use for neria™ infusion sets?

A neria™ infusion set is a range of soft catheter or steel needle infusion sets designed for subcutaneous drug delivery. The products have been designed to be compatible with certain drugs approved for subcutaneous infusion for the treatment of Parkinson’s Disease1 Primary Immunodeficiency1 Pain Management1 and Thalassaemia1 (see next question for more detailed information).

1. Statement - Overview of Drug/Device Compatibility Test for the neria™ Range. 24. February 2020. AP-020446-MM. Data on file. Unomedical A/S.

How long can neria™ infusion sets be left in place on the body?

It is recommended that a neria™ infusion set is changed after 72 hours for a soft catheter or 24 hours for a steel needle. Please always consult with your healthcare professional on when and how to change your infusion set.

Change the infusion set in consultation with your healthcare provider following the below recommendations:

Disease neria™ guard neria™ soft 90 neria™ soft neria™ multi neria™ detach neria™
Parkinson´s Disease 12 h 12 h 12 h   12 h 12 h
Primary Immune Deficiency 12 h 12 h 12 h 12 h 12 h 12 h
Thalasseamia           18 h
Pain Management 72 h 72 h 72 h   48 h 48 h

Please also follow the recommendations in both drug and device instructions for use.

What is the priming volume of neria™ infusion set lines?

Below are the approximate priming volumes for each tubing length. 

Tubing length (cm) Priming volume
12 cm ~ 0.04 ml
30 cm ~ 0.06 ml
60 cm ~ 0.10 ml
80 cm ~ 0.12 ml
110 cm ~ 0.15 ml

Please also read the instructions for use which comes with the product.

Can I use neria™ infusion sets for intravenous (IV) drug delivery?

The neria™ infusion sets are specifically designed for subcutaneous drug delivery. For this reason, they are not intended for IV infusion of medication.

Is the product needle safe?

neria™ guard and neria™ soft 90 are needle safe products that protect users from needle stick injuries.

neria™ guard is a fully automatic infusion set, with a passive needle safety feature, where the user does not see and is not exposed to the needle at any time. The neria™ soft 90 has an active needle safety feature where the user can cover the needle directly after use to prevent needle stick injuries (NSI).

Product features (pump, needle, adhesive dressing, drugs)

Which drugs have neria™ infusion sets been tested with?

Stability testing has been carried out with the following drugs for the treatment of the four diseases below:

  • Apomorphine for Parkinson’s Disease1
  • Immunoglobulins for Immune deficiencies1
  • Morphine and hydromorphone for pain management1
  • Desferal™ for Thalasseamia1

The table below shows which infusion sets are indicated for which specific disease.

Disease neria™ guard neria™ soft 90 neria™ soft neria™ multi neria™ detach neria™
Parkinson´s Disease X X X   X X
Immune Deficiencies X X X X X X
Thalassaemia           X
Pain Management X X X   X X

1.Statement - Overview of Drug/Device Compatibility Test for the neria™ Range. 24. February 2020. AP-020446-MM. Data on file. Unomedical A/S.

Will neria™ infusion sets fit/work with all pumps?

neria™ infusion sets have a standard luer lock connector and will fit most available infusion pumps.

Do I need additional adhesive dressing when using neria™ infusion sets?

No, neria™ infusion sets have a built-in skin-friendly adhesive pad which makes any extra adhesive dressing unnecessary.

Is the neria™ infusion set tubing kink-resistant?

neria™ infusion sets are constructed with a strong high quality double layer tubing to support the continuous flow of drugs.

What is the purpose of the caps in the blister pack?

When disconnecting the tubing, you can use the caps to give a more smooth surface at the site (cannula housing). The caps are included in the soft-catheter infusion sets (neria™ guard, neria™ soft 90, neria™ soft) and one of our steel needle products (neria™ detach). 

Insertion site

What are the recommended insertion sites for subcutaneous drug delivery?

The most commonly used insertion sites for subcutaneous therapy are on the abdomen and lower back. Please read the product's instructions for use and discuss possible insertion sites with your healthcare professional.

Healthcare professionals should always take into account any local guidelines and protocols.

How can I help prevent site irritation?
  • Always clean and dry the insertion site prior to insertion.
  • Massage the insertion site prior to insertion.
  • Monitor the insertion site through the “window” of the soft catheter infusion set.
  • Make sure to rotate the sites using one of the recommended patterns (for instance S-shape or clockwise).
  • An easy insertion technique can also be beneficial for the patient and help prevent site irritation.
  • Use a fine needle design - all neria™ infusions sets have high quality needles with the option of G27 and G29 sizes for certain products.
  • Consider switching to a soft cannula infusion set and/or a shorter needle/soft catheter when faced with insertion site problems.
  • If site irritation occurs, change the infusion set to a new site and massage the skin.

Please also read our trouble shooting guide under each therapeutic area on the website.

Healthcare professionals should always take into account any local guidelines and protocols.

How do I help prevent nodule formations?

Many factors can influence the condition of your skin. To minimize skin complications, consider:
- improving hygiene on skin and hands prior to insertion
- using more areas for insertion, for instance the lower back and thighs
- using a rotation pattern to avoid re-using the same site 
- avoiding sites that already have site irritation or nodules
- using a site that does not interfere with clothing, belts etc.
- massaging the infusion site prior to insertion
- changing the catheter material (from steel to soft), length or insertion technique.

Please also read our poster discussing Parkinson's Disease and the subcutaneous delivery route.

Patients and caregivers

What patient types are neria™ infusion sets suitable for?

neria™ infusion sets come with different needle sizes and tubing lengths, making them suitable for all patient types. For maximum absorption of subcutaneous drugs, the needle or soft catheter should be positioned in the adipose fat layer below the skin. If the needle goes too deeply into the muscle layer, this could impair or prevent drug absorption.

  • The choice of soft cannula or needle length should be based on treatment and patient specific factors such as physiology and activity level. A too long soft cannula or needle may result in insertion pain and/or insertion into a bone or muscle and a too short soft cannula or needle in leakage or irritation at the insertion site.
  • The choice of needle gauge (width of the needle) also depends on the drug to be administered. A G29 needle is a very thin and fine needle, whereas a G27 needle has a wider bore and is used for more viscous drug preparations (i.e. immunoglobulins).
  • For very lean and active patients, a shorter needle or neria™ soft with an angled insertion may be more suitable.
  • The different tubing lengths accommodate the needs of patients and the position of the pump.

Please always consult drug and pump manufacturer’s instructions for use prior to choosing the appropriate infusion set.

Can patients or their caregiver set up their own subcutaneous therapy using neria™ infusion sets?

Yes, all neria™ infusion sets are designed for and support self-management. The simple 90-degree insertion technique supports patient self-management and numerous patients and caregivers worldwide handle their own therapy with neria™ infusion sets.

The most user-friendly product for self-management is neria™ guard - a simple to use and fully automatic infusion set with few user steps for quick and easy 90-degree insertion. This simple and quick insertion method supports patient self-management and has no visible needle at any time.1,2

1. D020-000144 Summative Usability Test Report, August 2017, Data on file, Unomedical a/s., 2. User perceptions and preferences using the neria guard infusion set compared with conventional infusion sets indicated for the treatment of Pain, Parkinson´s Disease, primary immune deficiencies, Thalasseamia and mild/ moderate rehydration (Hypodermoclysis), April 2019,Data on file, Unomedical a/s.

Is it safe to shower or swim with the infusion set?

Yes, if you are using a soft catheter infusion set (neria™ guard, neria™ soft90, neria™ soft) or the steel needle product neria™ detach. With these products you can disconnect the pump and tubing from the housing.

Removal and disposal

How do I remove my infusion set?

Remove the infusion set by carefully loosening the adhesive dressing around the housing before pulling the needle/soft catheter out of the skin.

How do I dispose of my infusion set?

Dispose of the infusion set according to local recommendations.

Please contact your local pharmacy for guidelines on how to dispose of the used infusion sets.