neria™ infusion sets are medical devices designed for subcutaneous drug delivery. The infusion set is located in the subcutaneous tissues and connects the pump or syringe to the body.

The components of an infusion set include: 

1. Needle and/or cannula - the cannula is inserted under the skin using an introducer needle
2. Adhesive dressing - built-in and skin friendly adhesive pad
3. Tubing – a double layer tubing that prevents kinking and secures the flow of medication to the tissue
4. Luer lock connector – a standard connector to the syringe or pump

A neria™ infusion set is a range of soft catheter or steel needle infusion sets designed for subcutaneous drug delivery. The products have been designed to be compatible with certain drugs approved for subcutaneous infusion for the treatment of Parkinson’s Disease¹ Primary Immunodeficiency¹ Pain Management¹ and Thalassaemia¹ (see next question for more detailed information).

^{1. Statement - Overview of Drug/Device Compatibility Test for the neria™ Range. 24. February 2020. AP-020446-MM. Data on file. Unomedical A/S.}

It is recommended that a neria™ infusion set is changed after 72 hours for a soft catheter or 24 hours for a steel needle. Please always consult with your healthcare professional on when and how to change your infusion set.

Change the infusion set in consultation with your healthcare provider following the below recommendations:

Below are the approximate priming volumes for each tubing length. 

The neria™ infusion sets are specifically designed for subcutaneous drug delivery. For this reason, they are not intended for IV infusion of medication.

neria™ guard and neria™ soft 90 are needle safe products that protect users from needle stick injuries.

neria™ guard is a fully automatic infusion set, with a passive needle safety feature, where the user does not see and is not exposed to the needle at any time. The neria™ soft 90 has an active needle safety feature where the user can cover the needle directly after use to prevent needle stick injuries (NSI).

Stability testing has been carried out with the following drugs for the treatment of the four diseases below:

• Apomorphine for Parkinson’s Disease¹
• Immunoglobulins for Immune deficiencies¹
• Morphine and hydromorphone for pain management¹
• Desferal™ for Thalasseamia¹

The table below shows which infusion sets are indicated for which specific disease.

neria™ infusion sets have a standard luer lock connector and will fit most available infusion pumps.

No, neria™ infusion sets have a built-in skin-friendly adhesive pad which makes any extra adhesive dressing unnecessary.

neria™ infusion sets are constructed with a strong high quality double layer tubing to support the continuous flow of drugs.

When disconnecting the tubing, you can use the caps to give a more smooth surface at the site (cannula housing). The caps are included in the soft-catheter infusion sets (neria™ guard, neria™ soft 90, neria™ soft) and one of our steel needle products (neria™ detach). 

The most commonly used insertion sites for subcutaneous therapy are on the abdomen and lower back. Please read the product's instructions for use and discuss possible insertion sites with your healthcare professional.

Healthcare professionals should always take into account any local guidelines and protocols.

• Always clean and dry the insertion site prior to insertion.
• Massage the insertion site prior to insertion.
• Monitor the insertion site through the “window” of the soft catheter infusion set.
• Make sure to rotate the sites using one of the recommended patterns (for instance S-shape or clockwise).
• An easy insertion technique can also be beneficial for the patient and help prevent site irritation.
• Use a fine needle design - all neria™ infusions sets have high quality needles with the option of G27 and G29 sizes for certain products.
• Consider switching to a soft cannula infusion set and/or a shorter needle/soft catheter when faced with insertion site problems.
• If site irritation occurs, change the infusion set to a new site and massage the skin.

Please also read our trouble shooting guide under each therapeutic area on the website.

Healthcare professionals should always take into account any local guidelines and protocols.

Many factors can influence the condition of your skin. To minimize skin complications, consider:
- improving hygiene on skin and hands prior to insertion
- using more areas for insertion, for instance the lower back and thighs
- using a rotation pattern to avoid re-using the same site 
- avoiding sites that already have site irritation or nodules
- using a site that does not interfere with clothing, belts etc.
- massaging the infusion site prior to insertion
- changing the catheter material (from steel to soft), length or insertion technique.

Please also read our poster discussing Parkinson's Disease and the subcutaneous delivery route.

neria™ infusion sets come with different needle sizes and tubing lengths, making them suitable for all patient types. For maximum absorption of subcutaneous drugs, the needle or soft catheter should be positioned in the adipose fat layer below the skin. If the needle goes too deeply into the muscle layer, this could impair or prevent drug absorption.

• The choice of soft cannula or needle length should be based on treatment and patient specific factors such as physiology and activity level. A too long soft cannula or needle may result in insertion pain and/or insertion into a bone or muscle and a too short soft cannula or needle in leakage or irritation at the insertion site.
• The choice of needle gauge (width of the needle) also depends on the drug to be administered. A G29 needle is a very thin and fine needle, whereas a G27 needle has a wider bore and is used for more viscous drug preparations (i.e. immunoglobulins).
• For very lean and active patients, a shorter needle or neria™ soft with an angled insertion may be more suitable.
• The different tubing lengths accommodate the needs of patients and the position of the pump.
  
  

Please always consult drug and pump manufacturer’s instructions for use prior to choosing the appropriate infusion set.

Yes, all neria™ infusion sets are designed for and support self-management. The simple 90-degree insertion technique supports patient self-management and numerous patients and caregivers worldwide handle their own therapy with neria™ infusion sets.

The most user-friendly product for self-management is neria™ guard - a simple to use and fully automatic infusion set with few user steps for quick and easy 90-degree insertion. This simple and quick insertion method supports patient self-management and has no visible needle at any time.^1,2

^{1. D020-000144 Summative Usability Test Report, August 2017, Data on file, Unomedical a/s., 2. User perceptions and preferences using the neria guard infusion set compared with conventional infusion sets indicated for the treatment of Pain, Parkinson´s Disease, primary immune deficiencies, Thalasseamia and mild/ moderate rehydration (Hypodermoclysis), April 2019,Data on file, Unomedical a/s.}

Yes, if you are using a soft catheter infusion set (neria™ guard, neria™ soft90, neria™ soft) or the steel needle product neria™ detach. With these products you can disconnect the pump and tubing from the housing.

Remove the infusion set by carefully loosening the adhesive dressing around the housing before pulling the needle/soft catheter out of the skin.

Dispose of the infusion set according to local recommendations.

Please contact your local pharmacy for guidelines on how to dispose of the used infusion sets.